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Annulated Diketopiperazines from Dipeptides or Schöllkopf Reagents via Tandem Cyclization−Intramolecular N-Arylation

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journal contribution
posted on 07.05.2010, 00:00 by Hwan Jung Lim, Judith C. Gallucci, T. V. RajanBabu
Facile CuI-mediated N-arylation of diketopiperazine using the Fukuyama modification of the Ullmann−Goldberg reaction can be exploited in new approaches to enantiopure polycyclic diketopiperazines from easily assembled dipeptides or functionalized Schöllkopf reagents.