American Chemical Society
ol051497q_si_001.pdf (91.06 kB)

Anion Recognition Using Preorganized Thiourea Functionalized [3]Polynorbornane Receptors

Download (91.06 kB)
journal contribution
posted on 2005-11-24, 00:00 authored by Frederick M. Pfeffer, Thorfinnur Gunnlaugsson, Paul Jensen, Paul E. Kruger
A new family of [3]polynorbornane frameworks exhibiting conformationally preorganized aromatic thiourea (cleft-like) receptors have been designed and synthesized for anion recognition. These show excellent affinity for the biologically relevant dihydrogenphosphate (H2PO4-) and dihydrogenpyrophosphate (H2P2O72-) anions (among others), which are bound in 1:1 and 2:1 (host:anion) ratio, respectively. Moreover, visually striking color changes accompany guest binding, enabling this family to act as colorimetric anion sensors.