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An Ichip-Domesticated Sponge Bacterium Produces an N‑Acyltyrosine Bearing an α‑Methyl Substituent

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journal contribution
posted on 16.09.2019, 13:04 by Logan W. MacIntyre, Marie J. Charles, Bradley A. Haltli, Douglas H. Marchbank, Russell G. Kerr
The ichip (isolation chip) was employed for the first time in a marine sponge (Xestospongia muta), and a putatively new bacterial species, Alteromonas sp. RKMC-009, was isolated. Strain RKMC-009 produces a novel N-acyltyrosine (1) that is appended with a rare α-methyl substituent within the aminoacyl moiety and also exhibits Gram-positive antibacterial activity. We determined through an SAR experiment that the α-methyl is necessary for Staphylococcus activity of 1 and that it enhances Enterococcus activity.