American Chemical Society
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An Epiisopicropodophyllin Aza Analogue via Palladium-Catalyzed Pseudo-Domino Cyclization

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journal contribution
posted on 2002-11-21, 00:00 authored by Giovanni Poli, Giuliano Giambastiani
A new aza analogue of epiisopicropodophyllin (the C-3 epimer of podophyllotoxin) has been synthesized exploiting two original strategic steps. Rings A/B and E are entered at an early stage via a cationic benzhydrylation process. A palladium-catalyzed pseudo-domino (Pd-PDOM) intramolecular process generates rings C/D in a single synthetic operation.