posted on 2007-11-22, 00:00authored byJakob Norinder, Krisztián Bogár, Lisa Kanupp, Jan-E. Bäckvall
Dynamic kinetic resolution of allylic alcohols to allylic acetates followed by copper-catalyzed allylic substitution gave alkenes in high yields
and high optical purity. Subsequent oxidative C−C double bond cleavage afforded pharmaceutically important α-methyl substituted carboxylic
acids in high ee.