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An Efficient Total Synthesis of (±)-Lycoramine

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journal contribution
posted on 09.12.2004, 00:00 by Chun-An Fan, Yong-Qiang Tu, Zhen-Lei Song, En Zhang, Lei Shi, Min Wang, Baomin Wang, Shu-Yu Zhang
A short and unique approach to (±)-lycoramine as one of the galanthamine-type alkaloids has been efficiently developed. The alternative advantage lies in that three stereocenters, including a crucial quaternary carbon center, were constructed with high diasteroselectivity via a key one-step NBS-mediated semipinacol rearrangement of the allylic alcohol.