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An Efficient Synthesis of Enamides from Ketones

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journal contribution
posted on 07.02.2008, 00:00 by Hang Zhao, Charles P. Vandenbossche, Stefan G. Koenig, Surendra P. Singh, Roger P. Bakale
A new synthesis of enamides from ketones is disclosed that involves a phosphine-mediated reductive acylation of oximes. The resulting enamides are isolated in good yields (up to 89%) and excellent purity, permitting a subsequent hydrogenation to access enantiopure acetamides at catalyst loadings practical for large-scale applications.