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An Efficient Synthesis of 3-Substituted 3H-Pyrimidin-4-ones

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journal contribution
posted on 18.03.2004, 00:00 by Jae Uk Jeong, Xiaohong Chen, Attiq Rahman, Dennis S. Yamashita, Juan I. Luengo
A novel and practical synthesis of 3-substituted 3H-pyrimidin-4-ones is described. The key step involves the cyclization of enamide esters, derived from readily available β-keto esters, with trimethylaluminum and various primary amines.