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An Efficient One-Pot Asymmetric Synthesis of Biaryl Compounds via Diels−Alder/Retro-Diels−Alder Cascade Reactions

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journal contribution
posted on 2007-03-01, 00:00 authored by Yongxiang Liu, Kui Lu, Mingji Dai, Kai Wang, Wanqing Wu, Jiahua Chen, Junmin Quan, Zhen Yang
A single-step chirality transfer method for the synthesis of axially chiral biaryl compounds by construction of the second aromatic ring via a Diels−Alder/retro-Diels−Alder cascade reaction is reported. This methodology should find broad application in the synthesis of natural products and asymmetric catalysts.

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