An Efficient One-Pot Asymmetric Synthesis of Biaryl Compounds via Diels−Alder/Retro-Diels−Alder Cascade Reactions

A single-step chirality transfer method for the synthesis of axially chiral biaryl compounds by construction of the second aromatic ring via a Diels−Alder/retro-Diels−Alder cascade reaction is reported. This methodology should find broad application in the synthesis of natural products and asymmetric catalysts.