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An Efficient Chitosan/Silica Composite Core–Shell Microspheres-Supported Pd Catalyst for Aryl Iodides Sonogashira Coupling Reactions

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journal contribution
posted on 07.12.2016, 00:00 by Qing Cui, Hong Zhao, Guangsheng Luo, Jianhong Xu
Monodispersed chitosan/silica core–shell microspheres-supported Pd catalysts were prepared by a simple and affordable microfluidic device. Merely 5 mg of supported Pd catalyst (1 wt %) showed superior capability in Sonogashira coupling reactions between various aryl iodides and terminal alkynes in a mild environment (ligand-free, copper-free, amine-free, water–ethanol as solvent at 65 °C) even after eight cycles of use. These novel porous composite microspheres provide a new carrier to reduce the loading, enhance the activity, and increase the stability of noble metal catalyst.