American Chemical Society
ol1c03224_si_001.pdf (7.97 MB)

An Efficient Approach for 3,3-Disubstituted Oxindoles Synthesis: Aryl Iodine Catalyzed Intramolecular C–N Bond Oxidative Cross-Coupling

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journal contribution
posted on 2021-10-28, 17:04 authored by Yang Wang, Mo Yang, Yuan-Yuan Sun, Zheng-Guang Wu, Hong Dai, Shuhua Li
Herein, we report the first intramolecular C–N bond formation of phenylpropanamide derivatives via organocatalytic oxidative reactions, affording 3,3-disubstituted oxindole derivatives with up to 99% yield. The high efficiency of this reaction is exemplified by the transition metal-free mild conditions and the ability to perform the reaction on a gram scale. Meanwhile, the DFT calculation of the catalytic oxidative transformation pathway has also been studied.