posted on 2020-03-16, 18:05authored byPellegrino La Manna, Carmen Talotta, Margherita De Rosa, Annunziata Soriente, Carmine Gaeta, Placido Neri
Here is reported
the first example of an organocatalyzed coupling
between pyrrole and isocyanates in a nanoconfined space. The hexameric
resorcinarene capsule C is able to catalyze the direct
coupling between isocyanates and pyrroles to give amidopyrroles with
excellent yields and selectivities. The reaction catalyzed by C prevents the use of expensive and poorly atom-economical
reagents. As in natural enzymes, the cavity of C is able
to discriminate between isomeric substrates.