An Acetic Acid-Promoted Strecker Type Reaction of N,N-Disubstituted Aminomalononitriles: An Efficient Way for the Construction of α‑Aminonitriles
journal contribution
posted on 2025-03-25, 22:03 authored by Bo-Wen Wang, Yan-Lin Pu, Run-Ze Li, Bai-Yang Li, Hai-Juan Jiao, Yin-Liang Bai, Wen Bao, Ye Zhang, Dao-Yong Zhu, Shao-Hua WangA Strecker type reaction between aldehydes and readily
available N,N-disubstituted aminomalononitriles has
been realized
for the first time to give an alternative strategy for the synthesis
of α-aminonitriles. This reaction features broad substrate scope
and the use of water as solvent, and its utility has been supported
by the formal synthesis of racemic Clopidogrel and a 3-aminoindole
type of compound.
