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Amphidinolide Y, a Novel 17-Membered Macrolide from Dinoflagellate Amphidinium sp.:  Plausible Biogenetic Precursor of Amphidinolide X

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posted on 14.11.2003, 00:00 by Masashi Tsuda, Naoko Izui, Kazutaka Shimbo, Masaaki Sato, Eri Fukushi, Jun Kawabata, Jun'ichi Kobayashi
A novel cytotoxic 17-membered macrolide, amphidinolide Y (1), has been isolated from a marine dinoflagellate Amphidinium sp., and it was elucidated to exist as a 9:1 equilibrium mixture of 6-keto- and 6(9)-hemiacetal forms (1a and 1b, respectively) on the basis of 2D NMR data and chemical means. The feeding experiments with 13C-labeled acetates suggested that amphidinolide Y (1) may be a biogenetic precursor of 16-membered macrodiolide, amphidinolide X (2).

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