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Amphidinins C–F, Amphidinolide Q Analogues from Marine Dinoflagellate Amphidinium sp.

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journal contribution
posted on 07.11.2014, 00:00 by Takaaki Kubota, Takahiro Iwai, Kanae Sakai, Tohru Gonoi, Jun’ichi Kobayashi
Four new polyketides, amphidinins C–F (14), have been isolated from the culture broth of symbiotic dinoflagellate Amphidinium sp. The analysis of their spectral data revealed that amphidinins C–F (14) were 4,5-seco-analogues of amphidinolide Q (5). The absolute configurations of the new compounds were elucidated by the combination of J-based configuration analysis, modified Mosher’s method, and chemical derivatization. Amphidinins D (2) and F (4) are the first glycosides related to amphidinolides. Amphidinins C–F (14) showed antimicrobial activity against bacteria and/or fungi.