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Ammonia as Ultimate Amino Source in Synthesis of Primary Amines via Nickel-Promoted C–H Bond Amination

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journal contribution
posted on 28.06.2019, 20:16 by Lin Yu, Chan Yang, Yongqi Yu, Da Liu, Liang Hu, Yuanjiu Xiao, Ze-Nan Song, Ze Tan
The direct use of ammonia in transition-metal promoted C–H bond amination for the synthesis of primary amines is considered to be one of the major challenges in synthetic organic chemistry. Herein, we report that such transformation can be successfully achieved via nickel-promoted amination of inert arene C–H bonds with ammonia gas assisted by an 8-amino-quinoline directing group.