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Aminolysis of Epoxides in a Microreactor System: A Continuous Flow Approach to β-Amino Alcohols

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journal contribution
posted on 19.03.2010, 00:00 by Matthew W. Bedore, Nikolay Zaborenko, Klavs F. Jensen, Timothy F. Jamison
The use of a continuous flow microreactor for β-amino alcohol formation by epoxide aminolysis is evaluated. Comparison to microwave batch reactions reveals that conditions obtainable in the microreactor can match or improve yields in many cases. By increasing the pressure of the system, maximum temperatures can also exceed those accessible using a microwave unit. The use of a microreactor for epoxide aminolysis reactions in the synthesis of two pharmaceutical relevant compounds is described.

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