posted on 2013-03-15, 00:00authored byMichael
F. Albers, Christian Hedberg
Phosphocholination of eukaryotic host cell proteins has
recently
been identified as a novel post-translational modification important
for bacterial pathogenesis. Here, we describe the first straightforward
synthetic strategy for peptides containing phosphocholinated serine,
threonine, or tyrosine residues using preformed functional amino acid
building blocks, fully compatible with standard Fmoc solid-phase peptide
synthesis.