American Chemical Society
ol9b03961_si_001.pdf (2.48 MB)

Amination of Aryl Boronic Acids with Alkylnitrites: A Convenient Complement to Cu-Promoted Reductive Amination

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journal contribution
posted on 2019-12-04, 19:34 authored by Oleg A. Levitskiy, Tatiana V. Magdesieva
Copper-catalyzed amination of aryl boronic acids with alkylnitrites leading to symmetrical diarylamines with a practical 50–80% yield was elaborated. Two C­(sp2)–N bonds are formed in the one-pot process under mild conditions. This new approach to diarylamines is a complement to the Cu-assisted reductive amination of aryl boronic acids avoiding preliminary synthesis of nitrosoarenes. The possible reaction scheme based on quantum chemical calculations was suggested, clarifying key intermediates.