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Amide-Ligand-Controlled Highly para-Selective Arylation of Monosubstituted Simple Arenes with Arylboronic Acids

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journal contribution
posted on 23.01.2017, 00:00 by Yu-Xin Luan, Tao Zhang, Wei-Wei Yao, Ke Lu, Lu-Yao Kong, Yu-Tong Lin, Mengchun Ye
Pd-catalyzed highly para-selective arylations of monosubstituted simple arenes with arylboronic acids to widely existed biaryls have been developed. Inspired by requisite amide-directing groups in reported selective oxidative couplings, amide ligands, especially DMF, are designed and found to be critical for the selectivity control in current arylations.

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