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Amidation of Saturated C−H Bonds Catalyzed by Electron-Deficient Ruthenium and Manganese Porphyrins. A Highly Catalytic Nitrogen Atom Transfer Process

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journal contribution
posted on 24.06.2000, 00:00 by Xiao-Qi Yu, Jie-Sheng Huang, Xiang-Ge Zhou, Chi-Ming Che
Amidation of a variety of hydrocarbons with PhINTs catalyzed by ruthenium and manganese meso-tetrakis(pentafluorophenyl)porphyrins 1 and 2 afforded N-substituted amides in up to 92% yields with good to excellent substrate conversions. By employing catalyst 2, exceptionally high turnovers (up to 2600) were achieved, and the amidations can be effected by directly using PhI(OAc)2/NH2R as amidating reagents; in the case of R = COCF3 a direct amination was realized in up to 90% yield.