American Chemical Society
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Ambient Temperature Nitrogen-Directed Difluoroalkynylborane Carboni−Lindsey Cycloaddition Reactions

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journal contribution
posted on 2010-01-01, 00:00 authored by Jérôme F. Vivat, Harry Adams, Joseph P. A. Harrity
The in situ generation of alkynyldifluoroboranes in the presence of N-heterocycle substituted tetrazines provides a convenient and direct method for the synthesis of pyridazine difluoroboranes. The reactions proceed in 10 min under ambient conditions and provide the opportunity to assemble unsymmetrical products with complete regiocontrol.