ol0c01906_si_001.pdf (5.22 MB)
Alternating Current Electrolysis for Organic Electrosynthesis: Trifluoromethylation of (Hetero)arenes
journal contribution
posted on 2020-07-13, 15:04 authored by Sachini Rodrigo, Chanchamnan Um, Jason C. Mixdorf, Disni Gunasekera, Hien M. Nguyen, Long LuoPaired electrolysis has a limited
reaction scope for organic synthesis
because it is often not compatible with reactions involving short-lived
intermediates. We addressed this limitation using alternating current
electrolysis (ACE). Using trifluoromethylation of (hetero)arenes as
a model reaction, we showed that the yield was improved from 13% using
paired electrolysis to 84% using ACE. We have also developed a theory
for guiding the rational design of reaction parameters for future
applications of ACE.