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Alkylamination of Styrenes with Alkyl N‑Hydroxyphthalimide Esters and Amines by B(C6H5)3‑Facilitated Photoredox Catalysis

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journal contribution
posted on 19.10.2018, 20:33 by Xuan-Hui Ouyang, Yang Li, Ren-Jie Song, Jin-Heng Li
A new, three-component 1,2-alkylamination of styrenes with alkyl N-hydroxyphthalimide (NHP) esters and amines by Lewis acid and visible-light photoredox cooperative catalysis is described. This reaction employs alkyl NHP esters as general alkylation reagents to accomplish the 1,2-alkylamination of alkenes in high efficiency and with excellent functional groups tolerance, significantly enhancing the synthetic potential of 1,2-alkylaminations of alkenes for accessing complex functionalized amines.