Alkene-Assisted Nickel-Catalyzed Regioselective 1,4-Addition of Organoboronic Acid to Dienones: A Direct Route to All-Carbon Quaternary Centers
journal contribution
posted on 2014-06-06, 00:00 authored by Ya-Chun Hong, Parthasarathy Gandeepan, Subramaniyan Mannathan, Wei-Tse Lee, Chien-Hong ChengA nickel-catalyzed
highly regioselective 1,4-addition reaction
of boronic acids to dienones to form products with an all-carbon quaternary
center is described. The 3-alkenyl group of dienones is the key for
the reaction to proceed smoothly. A mechanism involving the coordination
of the dienyl group to the nickel center is proposed.
