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Alkaloids with Different Carbon Units from Myrioneuron faberi

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journal contribution
posted on 2015-11-25, 00:00 authored by Ming-Ming Cao, Yu Zhang, Sheng-Dian Huang, Ying-Tong Di, Zong-Gen Peng, Jian-Dong Jiang, Chun-Mao Yuan, Duo-Zhi Chen, Shun-Lin Li, Hong-Ping He, Xiao-Jiang Hao
Three new Myrioneuron alkaloids, myrifamines A–C (13), with unique skeletons were isolated from Myrioneuron faberi. The absolute configuration of 1 was confirmed by single-crystal X-ray diffraction analysis, and the stereochemistry of the other two alkaloids was determined using a combination of ROESY experiments and calculated and experimental electronic circular dichroism spectra. Myrifamine C (3) is the first example of a symmetric dimer among the Myrioneuron alkaloids. Known alkaloids myrionamide (4) and schoberine (5) were also isolated, and experimental NMR and X-ray diffraction data suggest their structural revision. Compound 2 showed significant inhibitory activity toward the hepatitis C virus in vitro, with a therapeutic index (CC50/EC50) greater than 108.7.

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