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Download fileAlbumin Broadens the Antibacterial Capabilities of Nonantibiotic Small Molecule-Capped Gold Nanoparticles
journal contribution
posted on 2019-11-22, 15:34 authored by Zhencheng Sun, Wenshu Zheng, Guoshuai Zhu, Jie Lian, Jidong Wang, Ping Hui, Songliang He, Wenwen Chen, Xingyu JiangNonantibiotic small molecule-modified gold nanoparticles
(Au NPs)
show great potential as an alternative for commercial antibiotics,
yet their narrow antibacterial spectrum hinders the wide application
in clinics. We observe that Au NPs cofunctionalized with both bovine
serum albumin (BSA) and 4,6-diamino-2-pyrimidinethiol (DAPT) can generate
conjugates (Au_DAPT_BSA) with progressive antimicrobial activities,
including decreased minimal inhibitory concentration against Gram-negative
bacteria and extended antibacterial spectrum against Gram-positive
bacteria compared with DAPT-capped Au NPs (Au_DAPT). Au_DAPT_BSA induces
no drug resistance and can significantly decrease the number of bacteria
in the biofilms formed by Pseudomonas aeruginosa and Staphylococcus aureus. In addition,
Au_DAPT_BSA exhibit in vivo healing efficiency for mice with subcutaneous
abscesses caused by clinically isolated, multidrug resistant Escherichia coli or S. aureus without inducing detectable toxicity to the mammalian cells/animals.
Our findings provide a new strategy for strengthening nanomaterial-based
bactericides such as Au NPs, especially against drug-resistant bacterial
infections.
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Molecule-Capped Gold Nanoparticles NonantibioticGram-negative bacteriaStaphylococcus aureusspectrumvivo healing efficiencyGram-positive bacteriaAntibacterial CapabilitiesDAPTBSAserum albuminPseudomonas aeruginosadrug resistanceAlbumin BroadensEscherichia colimolecule-modified gold nanoparticlessubcutaneous abscessesnanomaterial-based bactericidesNPs cofunctionalizedantimicrobial activities