posted on 2019-04-17, 00:00authored byZhicheng Pan, Xueling He, Nijia Song, Danxuan Fang, Zhen Li, Jiehua Li, Feng Luo, Jianshu Li, Hong Tan, Qiang Fu
Cationic
nanocarriers have emerged as promising nanoparticle systems for the
effective delivery of nucleic acid and anticancer drugs to cancer
cells. A positive charge is desirable for promoting cell internalization,
whereas it also causes some adverse effects, such as toxicity and
rapid clearance by mononuclear phagocytic systems. Herein, a new strategy
of modifying cationic polymer micelles with albumin forming a protein
corona to improve the surface physiochemical properties is reported.
The corona with a monolayer or a multilayer was constructed depending
on the albumin concentration, and the proteins would denature in different
degrees due to the interaction with the surface of cationic micelles.
It is demonstrated that multilayer albumin corona is beneficial to
prevent macrophage uptake, increase accumulation in tumor tissues,
and reduce toxic side effects to normal tissues. Our work provides
a promising method to modify the cationic nanoplatform by optimizing
the biosecurity and bioavailability for potential application in drug
delivery.