Akanthomycin, a New Antibiotic
Pyridone from the Entomopathogenic
Fungus Akanthomyces gracilis

Wagenaar, Melissa M.; Gibson, Donna M.; Clardy, Jon

doi:10.1021/ol016737q.s001

Akanthomycin, a New Antibiotic Pyridone from the Entomopathogenic Fungus Akanthomyces gracilis

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posted on 2002-02-05, 00:00 authored by Melissa M. Wagenaar, Donna M. Gibson, Jon Clardy

Organic extracts of the entomopathogenic fungus Akanthomyces gracilis ARS 2910 contained antibiotics active against Staphylococcus aureus. Bioassay-guided fractionation of the CH₂Cl₂ extract yielded the antibacterial compound akanthomycin as a mixture of atropisomers along with the closely related compounds 8-methylpyridoxatin and cordypyridone C. Akanthomycin was characterized using X-ray crystallography and NMR.

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Entomopathogenic Fungus Akanthomyces g racilis Organic extracts antibiotic New Antibiotic Pyridone Staphylococcus aureus mixture fractionation crystallography CH 2 Cl 2 compound akanthomycin NMR methylpyridoxatin Akanthomycin cordypyridone C entomopathogenic fungus Akanthomyces gracilis ARS 2910 atropisomer

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Akanthomycin, a New Antibiotic Pyridone from the Entomopathogenic Fungus Akanthomyces gracilis

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