American Chemical Society
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Akanthomycin, a New Antibiotic Pyridone from the Entomopathogenic Fungus Akanthomyces gracilis

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journal contribution
posted on 2002-02-05, 00:00 authored by Melissa M. Wagenaar, Donna M. Gibson, Jon Clardy
Organic extracts of the entomopathogenic fungus Akanthomyces gracilis ARS 2910 contained antibiotics active against Staphylococcus aureus. Bioassay-guided fractionation of the CH2Cl2 extract yielded the antibacterial compound akanthomycin as a mixture of atropisomers along with the closely related compounds 8-methylpyridoxatin and cordypyridone C. Akanthomycin was characterized using X-ray crystallography and NMR.