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Ainsliadimer A, A New Sesquiterpene Lactone Dimer with an Unusual Carbon Skeleton from Ainsliaea macrocephala

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journal contribution
posted on 2008-06-19, 00:00 authored by Zhi-Jun Wu, Xi-Ke Xu, Yun-Heng Shen, Juan Su, Jun-Mian Tian, Shuang Liang, Hui-Liang Li, Rui-Hui Liu, Wei-Dong Zhang
A phytochemical investigation of Ainsliaea macrocephala led to the isolation of a new dimeric sesquiterpene lactone, ainsliadimer A (1). The structure of 1 was elucidated by spectroscopic analysis, and confirmed by single crystal X-ray diffraction. Ainsliadimer A represents an unusual carbon skeleton with a cyclopentane system connecting the two monomeric sesquiterpene lactone units. This unique molecule exerted potent inhibitory activity against the production of nitric oxide in RAW264.7 stimulated by LPS.