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Aglacins A−D, First Representatives of a New Class of Aryltetralin Cyclic Ether Lignans from Aglaia cordata

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journal contribution
posted on 22.11.2001, 00:00 by Bin-Gui Wang, Rainer Ebel, Bambang W. Nugroho, Djoko Prijono, Walter Frank, Klaus G. Steube, Xiao-Jiang Hao, Peter Proksch
Four new metabolites, aglacins A−D (14), were identified from the methanol extract of the stem bark of Aglaia cordata. These compounds represent a new class of aryltetralin cyclic ether lignan. The structure of aglacin A (1) including the absolute configuration was elucidated by interpretation of spectral data, X-ray crystal structure determination, and employing the modified Mosher's method. In addition, three other derivatives, aglacins B−D (24), were isolated and identified by spectral means.