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Download fileAggregation Behavior of Amphiphilic p(HPMA)-co-p(LMA) Copolymers Studied by FCS and EPR Spectroscopy
journal contribution
posted on 2012-12-10, 00:00 authored by Mirjam Hemmelmann, Dennis Kurzbach, Kaloian Koynov, Dariush Hinderberger, Rudolf ZentelA combined study of fluorescence correlation spectroscopy
and electron
paramagnetic resonance spectroscopy gave a unique picture of p(HPMA)-co-p(LMA) copolymers in aqueous solutions, ranging from
the size of micelles and aggregates to the composition of the interior
of these self-assembled systems. P(HPMA)-co-p(LMA)
copolymers have shown high potential as brain drug delivery systems,
and a detailed study of their physicochemical properties can help
to elucidate their mechanism of action. Applying two complementary
techniques, we found that the self-assembly behavior as well as the
strength of hydrophobic attraction of the amphiphilic copolymers can
be tuned by the hydrophobic LMA content or the presence of hydrophobic
molecules or domains. Studies on the dependence of the hydrophobic
lauryl side chain content on the aggregation behavior revealed that
above 5 mol % laury side-chain copolymers self-assemble into intrachain
micelles and larger aggregates. Above this critical alkyl chain content,
p(HPMA)-co-p(LMA) copolymers can solubilize the model
drug domperidone and exhibit the tendency to interact with model cell
membranes.
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Keywords
fluorescence correlation spectroscopyaggregation behaviormodel drug domperidoneintrachain micellesbrain drug delivery systemsFCSEPR SpectroscopyAAggregation Behaviorresonance spectroscopymodel cell membranesamphiphilic copolymersalkyl chain contentphysicochemical propertieslauryl side chain contentLMA contentaggregate