American Chemical Society
ol4006954_si_001.pdf (8.86 MB)

Ag-Carbenoid-Initiated Catalytic Hydration Cascades: Rapid Construction of Functionalized Bicyclo[3.3.1]nonanes

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journal contribution
posted on 2016-02-19, 08:43 authored by Lu Wang, Shunyou Cai, Xiangyou Xing, Ying Gao, Tao Wang, David Zhigang Wang
Remarkable Ag-carbenoid-initiated enone cyclopropanation–hydrolytic fragmentation–competitive 1,2-vs-1,4 addition reaction cascades were uncovered on a range of propargylic esters tethered to cyclohexadienones, leading to the highly efficient and stereospecific construction of densely functionalized bicyclo[3.3.1]nonanes under mild conditions.