posted on 2018-07-11, 00:00authored byYou-Quan Zhu, Jing-Li He, Yun-Xia Niu, Hui-Ying Kang, Ting-Feng Han, Hao-Yu Li
A new
and facile AgSbF6-mediated protocol for the construction
of C-4 thiolated or selenylated isoquinolin-1(2H)-ones
via a radical pathway was established. This reaction proceeded efficiently
with excellent regioselectivity, a broad substrate scope, and good
functional group tolerance. A radical reaction mechanism involving
thiyl radicals as key intermediates is proposed for the present transformation.