AgNO2 as the NO Source for the Synthesis
of Substituted Pyrazole N‑Oxides from N‑Propargylamines

Yuan, Bingxiang; Zhang, Fuming; Li, Zhuomei; Yang, Shenghua; Yan, Rulong

doi:10.1021/acs.orglett.6b03021.s001

ol6b03021_si_001.pdf (5.65 MB)

AgNO₂ as the NO Source for the Synthesis of Substituted Pyrazole N‑Oxides from N‑Propargylamines

journal contribution

posted on 2016-11-01, 19:51 authored by Bingxiang Yuan, Fuming Zhang, Zhuomei Li, Shenghua Yang, Rulong Yan

A straightforward method for synthesizing the pyrazole N-oxides from N-propargylamines and AgNO₂ through oxidation/cyclization reaction had been developed. AgNO₂ was used as the NO source for the first time to synthesize pyrazole N-oxides. Various substituted groups on N-propargylamines proceeded smoothly, and the desired products were obtained in good yields.