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Advances in Proline Ligation

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journal contribution
posted on 29.02.2012, 00:00 by Steven D. Townsend, Zhongping Tan, Suwei Dong, Shiying Shang, John A. Brailsford, Samuel J. Danishefsky
Application of native chemical ligation logic to the case of an N-terminal proline is described. Two approaches were studied. One involved incorporation of a 3R-substituted thiyl-proline derivative. Improved results were obtained from a 3R-substituted selenol function, incorporated in the context of an oxidized dimer.