jp2095278_si_001.pdf (2.2 MB)
Adsorption of Doxorubicin onto Citrate-Stabilized Magnetic Nanoparticles
journal contribution
posted on 2012-03-08, 00:00 authored by Krzysztof Nawara, Jerzy Romiszewski, Krystyna Kijewska, Jacek Szczytko, Andrzej Twardowski, Maciej Mazur, Paweł KrysinskiWe have synthesized citric-acid-stabilized magnetic nanoparticles
with very good magnetization behavior and relatively low contribution
from shape and surface magnetic anisotropies. In this work, we report
also on a simple adsorption of doxorubicin onto the surface of these
nanoferrites that can provide a facile preparation process for potential
drug carriers. To estimate the amount of adsorbed doxorubicin, we
propose a novel method utilizing a ternary system for the determination
of interactions between drug and citric-acid-stabilized nanoparticles.
The Gibbs free enthalpy of adsorption was determined from Henry’s
isotherm that represents the drug adsorption profile within the studied
concentration range. The estimated value seems to be promising for
the preparation of drug-loaded nanoparticles solely by means of the
adsorption process. Additional encapsulation of doxorubicin-loaded
nanoparticles in an inert polypyrrole microvessel might provide a
protective surrounding for drug molecules. In our opinion, understanding
the physical interactions between doxorubicin and nanoparticles might
be a key factor governing drug release and overall pharmacodynamics.