Acylated Iridoids with Cytotoxicity from Valeriana jatamansi
journal contributionposted on 24.04.2009, 00:00 by Sheng Lin, Yun-Heng Shen, Hui-Liang Li, Xian-Wen Yang, Tao Chen, Long-Hai Lu, Zheng-Sheng Huang, Run-Hui Liu, Xi-Ke Xu, Wei-Dong Zhang, Hui Wang
Thirteen new acylated iridoids, jatamanvaltrates A−M (1−13), together with nine known valepotriates (14−22), were isolated from the whole plants of Valeriana jatamansi (syn. Valeriana wallichii). The structures of these new compounds were assigned by detailed interpretation of spectroscopic data. Jatamanvaltrates D (4) and H (9) are the first examples of naturally occurring valepotriates containing an o-hydroxybenzoyloxy moiety at C-10. All isolated compounds were tested for their cytotoxicity against lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines.