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Acylated Iridoids with Cytotoxicity from Valeriana jatamansi

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journal contribution
posted on 24.04.2009, 00:00 by Sheng Lin, Yun-Heng Shen, Hui-Liang Li, Xian-Wen Yang, Tao Chen, Long-Hai Lu, Zheng-Sheng Huang, Run-Hui Liu, Xi-Ke Xu, Wei-Dong Zhang, Hui Wang
Thirteen new acylated iridoids, jatamanvaltrates A−M (113), together with nine known valepotriates (1422), were isolated from the whole plants of Valeriana jatamansi (syn. Valeriana wallichii). The structures of these new compounds were assigned by detailed interpretation of spectroscopic data. Jatamanvaltrates D (4) and H (9) are the first examples of naturally occurring valepotriates containing an o-hydroxybenzoyloxy moiety at C-10. All isolated compounds were tested for their cytotoxicity against lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines.