American Chemical Society
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Acyl Radicals from α‑Keto Acids Using a Carbonyl Photocatalyst: Photoredox-Catalyzed Synthesis of Ketones

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journal contribution
posted on 2020-08-18, 11:40 authored by Da-Liang Zhu, Qi Wu, David James Young, Hao Wang, Zhi-Gang Ren, Hong-Xi Li
Acyl radicals have been generated from α-keto acids using inexpensive and commercially available 2-chloro-thioxanthen-9-one as the photoredox catalyst under visible light illumination. These reactive species added to olefins or coupled with aryl halides via a bipyridyl-stabilized Ni­(II) catalyst, enabling easy access to a diverse range of ketones. This reliable, atom-economical, and eco-friendly protocol is compatible with a wide range of functional groups.