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Download fileAcyl Radicals from α‑Keto Acids: Metal-Free Visible-Light-Promoted Acylation of Heterocycles
journal contribution
posted on 2021-03-29, 19:14 authored by Hu-Lin Zhu, Fan-Lin Zeng, Xiao-Lan Chen, Kai Sun, Hao-Cong Li, Xiao-Ya Yuan, Ling-Bo Qu, Bing YuA general
and metal-free visible-light-induced decarboxylative
arylation procedure at room temperature was described for the construction
of acylated heterocyclic derivatives, such as benzimidazo/indolo[2,1-a]isoquinolin-6(5H)-ones, aroylazaspiro[4.5]trienones,
thioflavones, and so on. This practical arylation procedure was conducted
by using 2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile
(4CzIPN) as a photocatalyst under mild conditions, which avoided the
use of an additional base, traditional heating, and metal reagents.