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Active Cobalt Catalyst for the Cleavage of Benzyl Ether

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journal contribution
posted on 22.02.2016, 14:34 authored by Bo Wang, Zhaojun Yin, Yangbing Li, Ting-Xiang Yang, Xiang-Bao Meng, Zhong-Jun Li
An improved method for the deprotection of benzyl ethers using a catalytic amount of Co2(CO)8 in the presence of Me2PhSiH and CO (1 atm) is described. The deprotection reaction is compatible with double bond or sulfur-containing substrates. The method also tolerates other functional groups, such as Ac, Piv, and Bz, and shows potential selectivity in perbenzylated monosaccharides.