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Activation and Alteration of Base Selectivity by Metal Cations in the Functionality-Transfer Reaction for RNA Modification

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journal contribution
posted on 18.08.2010, 00:00 authored by Kazumitsu Onizuka, Yosuke Taniguchi, Shigeki Sasaki
Previously, we reported that the 2-methylidene-1,3-diketone unit of 6-thioguanosine transferred selectively to the amino group of cytosine at pH 7.0 and that its selectivity was changed to the guanine base at pH 9.6. In this study, it was found that the functionality-transfer reaction enhanced selectivity for the guanine base in the presence of divalent transition metal cations such as Ni2+ and Co2+ at pH 7.4.