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Acetophenone Monomers from Acronychia trifoliolata

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journal contribution
posted on 24.10.2016, 17:53 by Katsunori Miyake, Airi Suzuki, Chihiro Morita, Masuo Goto, David J. Newman, Barry R. O’Keefe, Susan L. Morris-Natschke, Kuo-Hsiung Lee, Kyoko Nakagawa-Goto
Seven new [acronyculatins I–O (17)] and four known acetophenone monomers were isolated from a CH3OH/CH2Cl2 (1:1) extract (N089419) of Acronychia trifoliolata provided by the U.S. National Cancer Institute (NCI, Frederick, MD, USA). Their structures were characterized by using various NMR and HRMS techniques. Among the known compounds, the structure of acronyculatin B (8) was revised. Some of the isolated compounds were evaluated for antiproliferative activity against human cancer cell lines. While most of the tested compounds were not cytotoxic, acronyculatins I (1) and J (2) showed moderate antiproliferative activity.