Access to Polycyclic Sulfonyl Indolines via Fe(II)-Catalyzed or UV-Driven Formal [2 + 2 + 1] Cyclization Reactions of N‑((1H-indol-3-yl)methyl)propiolamides with NaHSO3

Lu, Lin; Luo, Chenguang; Peng, Hui; Jiang, Huanfeng; Lei, Ming; Yin, Biaolin

doi:10.1021/acs.orglett.9b00573.s001

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Access to Polycyclic Sulfonyl Indolines via Fe(II)-Catalyzed or UV-Driven Formal [2 + 2 + 1] Cyclization Reactions of N‑((1H-indol-3-yl)methyl)propiolamides with NaHSO₃

journal contribution

posted on 2019-04-08, 00:00 authored by Lin Lu, Chenguang Luo, Hui Peng, Huanfeng Jiang, Ming Lei, Biaolin Yin

A variety of structurally novel polycyclic sulfonyl indolines have been synthesized via FeCl₂-catalyzed or UV-driven intramolecular formal [2 + 2 + 1] dearomatizing cyclization reactions of N-(1H-indol-3-yl)methyl)propiolamides with NaHSO₃ in an aqueous medium. The reactions involve the formation of one C–C bond and two C–S bonds in a single step.