posted on 2024-01-03, 22:14authored byBubul Das, Nikita Chakraborty, Hirendra Nath Dhara, Pratip Bhattacharyya, Bhisma K. Patel
A mild and concise method for the
synthesis of chromenopyrrole
from 2′-hydroxychalcone is devised. The reaction proceeds via
an initial [3 + 2] cycloaddition on the CC bond of 2′-hydroxychalcone
and 1,3-dipolarophile, generated in situ by the reaction of ethyl
isocyanoacetate and AgOAc. This is then followed by an intramolecular
C–O bond formation with the −OH group and C5–H
of the in situ generated pyrrole, leading to chromenopyrroles.