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Access to 2,5-Diamidopyrroles and 2,5-Diamidofurans by Au(I)-Catalyzed Double Hydroamination or Hydration of 1,3-Diynes

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journal contribution
posted on 18.06.2010, 00:00 by Søren Kramer, Julie L. H. Madsen, Mario Rottländer, Troels Skrydstrup
A Au(I)-catalyzed hydroamination or hydration of 1,3-diynes to access 2,5-diamidopyrroles and 2,5-diamidofurans has been developed. This method can also be expanded to 2,5-disubstituted furans and 1,2,5-trisubstituted pyrroles including the formation of deuterated heterocycles and 18O-labeled furans.

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