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Acceptorless Dehydrogenative Coupling of o‑Aminobenzamides with the Activation of Methanol as a C1 Source for the Construction of Quinazolinones

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journal contribution
posted on 21.05.2016, 14:29 by Feng Li, Lei Lu, Pengcheng Liu
A strategy for the synthesis of quinazolinones via acceptorless coupling of o-aminobenzamides with methanol has been accomplished in the presence of the metal–ligand bifunctional catalyst [Cp*Ir­(2,2′-bpyO)­(H2O)]. Notably, this research exhibited the potential of transition-metal-catalyzed activation of methanol as a C1 source for the construction of heterocycles.