ol7017856_si_003.pdf (2.28 MB)
Download fileAbsolute Structure of Prunustatin A, a Novel GRP78 Molecular Chaperone Down-Regulator
journal contribution
posted on 11.10.2007, 00:00 authored by Yukiko Umeda, Kazuo Furihata, Shohei Sakuda, Hiromichi Nagasawa, Ken Ishigami, Hidenori Watanabe, Miho Izumikawa, Motoki Takagi, Takayuki Doi, Yoichi Nakao, Kazuo Shin-yaIn the course of our screening program for regulators of a molecular chaperone GRP78 expression, we isolated a novel inhibitor of GRP78
expression, designated as prunustatin A, from Streptomyces violaceoniger 4521-SVS3. The planar structure of prunustatin A was determined
to be an oxidized type of the neoantimycin family. Its absolute stereochemistry was established to be 2R, 4S, 6S, 7R, 9S, and 29S by analyzing
chemically degraded components obtained from the derivative of prunustatin A.