ol500173y_si_001.pdf (2.28 MB)
Download fileAbsolute Configuration Determination Using Enantiomeric Pairs of Molecularly Imprinted Polymers
journal contribution
posted on 2014-03-07, 00:00 authored by Danielle
S. Meador, David A. SpivakA new method for
determination of absolute configuration (AC) is
demonstrated using an enantiomeric pair of molecularly imprinted polymers,
referred to as “DuoMIPs”. The ratio of HPLC capacity
factors (k′) for the analyte on each of the
DuoMIPs is defined as the γ factor and can be used to determine
AC when above 1.2. A mnemonic based on the complementary binding geometry
of the DuoMIPs was used to aid in understanding and prediction of
AC.